Investigating how CYP1B1 protein interactions affect cancer development
Role of small molecule interactions and multiprotein assemblies in CYP1B1 disease-associated function and dysfunction
This study is looking at a protein called CYP1B1 that can act differently in cancer cells compared to healthy cells, and by understanding how it works, we hope to find new ways to help patients with cancer and improve their treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10654672 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the CYP1B1 protein, which is often overexpressed in tumors but present at low levels in healthy tissues. By examining how mutations and environmental factors influence the behavior of this protein, the study aims to uncover the mechanisms behind cancer initiation and progression. The research employs advanced microscopy techniques to observe the interactions and assembly of CYP1B1 with other proteins, which may lead to harmful effects in cancer cells. Patients may benefit from insights gained into how CYP1B1 contributes to cancer and resistance to treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cancers where CYP1B1 is known to be overexpressed, as well as those with hereditary conditions linked to CYP1B1 mutations.
Not a fit: Patients with cancers unrelated to CYP1B1 or those without any genetic predisposition linked to this protein may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting CYP1B1 in cancer therapies, improving treatment outcomes for patients.
How similar studies have performed: Other research has shown promising results in targeting similar proteins in cancer treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Richards, Christopher I — University of Kentucky
- Study coordinator: Richards, Christopher I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.