Investigating how cyclic nucleotide signaling affects aortic aneurysms
Role of cyclic nucleotide signaling in aortic aneurysm
This study is looking at how certain signals in the body affect the growth of aortic aneurysms, which are dangerous bulges in the main artery, to find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10846654 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cyclic nucleotide signaling in the development and progression of aortic aneurysms, which are dangerous bulges in the aorta. The study examines how specific enzymes that regulate cyclic nucleotides, such as cAMP and cGMP, influence the function of smooth muscle cells in the aorta. By exploring these mechanisms, the research aims to identify potential therapeutic targets that could improve treatment outcomes for patients with aortic aneurysms. The approach includes both laboratory experiments and analysis of existing clinical data to better understand the relationship between cyclic nucleotide signaling and aortic health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with aortic aneurysms, particularly those at risk of rupture.
Not a fit: Patients with aortic aneurysms who are not candidates for surgical intervention or those with other unrelated health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of aortic aneurysms and reduce the risk of life-threatening ruptures.
How similar studies have performed: Previous studies have shown promising results in targeting cyclic nucleotide signaling for cardiovascular conditions, suggesting potential for success in this area as well.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Yan, Chen — University of Rochester
- Study coordinator: Yan, Chen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.