Investigating how cyclic di-nucleotide signaling affects living organisms
Exploring cyclic di-nucleotide signaling across the tree of life
This study is looking at how certain molecules called cyclic di-nucleotides help our bodies respond to different signals from the environment, which could lead to better ways to treat infections and boost our immune system against viruses and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11011261 on NIH RePORTER |
What this research studies
This research explores the role of cyclic di-nucleotide (cdN) signaling, a crucial molecular mechanism that connects environmental signals to biological responses in various organisms, from bacteria to humans. It examines how cdNs influence important processes such as biofilm formation, stress responses, and immune system activation against viruses and cancer. By studying these signaling pathways, the research aims to uncover the diversity of cdN systems and their adaptive benefits, which could lead to new insights in treating bacterial infections and enhancing immune responses. The research employs a combination of genetic, biochemical, and cellular techniques to investigate these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bacterial infections or those at risk for cancer who may benefit from enhanced immune responses.
Not a fit: Patients with conditions unrelated to bacterial infections or immune system function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating bacterial infections and improving anti-cancer immune responses.
How similar studies have performed: Previous research has shown promising results in understanding cdN signaling in bacteria, but the application in eukaryotic systems is still relatively novel.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Waters, Christopher M — Michigan State University
- Study coordinator: Waters, Christopher M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.