Investigating how CTHRC1 affects cell survival after heart issues
Effect of CTHRC1 on endothelial cell survival after acute ischemia
This study is looking at a protein called CTHRC1 to see if higher levels in the blood can help patients who have had a cardiac arrest survive better, with the hope of finding new ways to support heart health during emergencies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10531574 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CTHRC1, a protein that may influence the survival of endothelial cells during acute ischemia, a condition where blood flow is restricted. The study examines how CTHRC1 levels in the blood correlate with survival rates in patients who have experienced cardiac arrest. By analyzing plasma samples from these patients, researchers aim to determine if higher levels of CTHRC1 can improve outcomes after heart-related events. This could lead to new therapeutic strategies for enhancing cell survival in critical situations.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced cardiac arrest or are at risk for cardiovascular diseases.
Not a fit: Patients with non-cardiovascular conditions or those who do not have detectable levels of CTHRC1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates for patients experiencing cardiac arrest by identifying a potential biomarker for treatment.
How similar studies have performed: Previous studies have indicated that elevated levels of CTHRC1 are associated with better survival outcomes in cardiac arrest patients, suggesting a promising avenue for further exploration.
Where this research is happening
Portland, United States
- Mainehealth — Portland, United States (Active)
Researchers
- Principal investigator: Lindner, Volkhard — Mainehealth
- Study coordinator: Lindner, Volkhard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.