Investigating how Crohn's disease affects growth differently in boys and girls
Official title: Sex Differences in Statural Growth Impairment in Pediatric Crohn's Disease: Part 2
Funded at Children's Research Institute · NIH-11141872 · Data updated 2026-11-12
This study is looking at how Crohn's disease affects the growth of children, especially comparing boys and girls, to find out what might be causing any growth issues and how to help kids grow better and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 11, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $667,497 |
| NIH project number | 5R01HD111638-03 |
| Project ID | NIH-11141872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Crohn's disease, particularly those experiencing growth impairment.
✕Less likely to help
Patients without Crohn's disease or those who are not experiencing growth issues may not benefit from this research.
What this research studies
This research focuses on understanding how pediatric Crohn's disease impacts growth in children, particularly examining the differences between boys and girls. It aims to identify the factors that contribute to growth impairment, such as inflammation, genetics, and nutrition. By analyzing data from previous studies, the researchers will explore how inflammation affects hormone levels that regulate growth, with the hypothesis that boys may be more severely impacted. The goal is to improve treatment strategies for children with Crohn's disease to enhance their growth and overall health.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options that promote normal growth in children with Crohn's disease.
How similar studies have gone: Previous studies have shown that understanding sex differences in disease impact can lead to improved treatment strategies, suggesting potential success for this research approach.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Gupta, Neera — Children's Research Institute
- Study coordinator: Gupta, Neera
Related research
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Metabolic signatures that predict outcomes in children with Crohn's
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.