Investigating how creatine metabolism affects necrotizing enterocolitis in infants
Official title: Role of Creatine Metabolism in Necrotizing Enterocolitis
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10724729 · Data updated 2026-11-12
This study is looking at how creatine, a natural substance, might help protect the intestines of premature babies from a serious condition called necrotizing enterocolitis (NEC) by improving their gut health and healing.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 5, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $398,750 |
| NIH project number | 1R21HD112659-01 |
| Project ID | NIH-10724729 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants, particularly those with very low birth weight who are at risk for necrotizing enterocolitis.
✕Less likely to help
Patients who are not premature or do not have very low birth weight may not benefit from this research.
What this research studies
This research focuses on necrotizing enterocolitis (NEC), a serious inflammatory condition that primarily affects premature infants. The study aims to explore the role of creatine, an amino acid derivative, in promoting intestinal health and resilience against NEC. By examining how creatine supplementation can improve intestinal barrier function and bioenergetics, the research seeks to identify nutritional strategies that could benefit vulnerable infants. The approach includes assessing the impact of creatine on intestinal cell function and healing processes.
Why it matters
Potential benefit: If successful, this research could lead to improved nutritional strategies that enhance intestinal health in premature infants, potentially reducing the incidence of necrotizing enterocolitis.
How similar studies have gone: Previous research has shown promising results regarding the benefits of creatine supplementation in improving intestinal health, suggesting that this approach may be effective.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Burge, Kathryn Young — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Burge, Kathryn Young
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.