Investigating how creatine metabolism affects breast cancer spread
Reprogramming of creatine metabolism in breast cancer metastasis
This study is looking at how a certain enzyme called CKMT1 affects the way breast cancer cells use creatine, which might help us understand how these cells spread to other parts of the body, and it could lead to new treatments for breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11030843 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific enzyme, CKMT1, in the metabolism of creatine within breast cancer cells. By examining how changes in creatine metabolism influence the ability of breast cancer cells to migrate and invade other tissues, the study aims to uncover new insights into cancer progression. The research involves analyzing cell lines, mouse models, and patient samples to determine the relationship between CKMT1 expression and breast cancer metastasis. The findings could lead to new therapeutic strategies targeting creatine metabolism in breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with metastatic disease.
Not a fit: Patients with non-breast cancers or those without active cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit breast cancer metastasis, improving patient outcomes.
How similar studies have performed: While the role of CKMT1 in breast cancer is not extensively studied, similar metabolic reprogramming approaches have shown promise in other cancer types.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Glunde, Kristine — Johns Hopkins University
- Study coordinator: Glunde, Kristine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.