Investigating how COVID-19 may contribute to Alzheimer's disease development
The role of SARS-CoV-2-induced senescence in the development of Alzheimer's Disease
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11134140
This study is looking at how COVID-19 might affect the brain and possibly lead to Alzheimer's disease, especially in older people, by examining how the virus interacts with brain cells, and it hopes to find new ways to help those who have had COVID-19 and are at risk for Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11134140 on ClinicalTrials.gov |
What this research studies
This research explores the connection between SARS-CoV-2 infection and the development of Alzheimer's disease, particularly focusing on how the virus may induce cellular senescence in the brain. The study will examine the effects of the virus's spike protein and systemic inflammation on brain cells, especially in older individuals. By using aged mice as a model, researchers aim to understand the mechanisms by which COVID-19 could exacerbate Alzheimer's pathology. The findings could provide insights into potential therapeutic targets for preventing or treating Alzheimer's disease in patients with a history of COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have had COVID-19 and are at risk for developing Alzheimer's disease.
Not a fit: Patients who have not had COVID-19 or do not have risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease in individuals affected by COVID-19.
How similar studies have performed: While the specific connection between COVID-19 and Alzheimer's disease is still being explored, related research has shown that viral infections can impact neurological health, suggesting potential for significant findings in this area.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARKOUTSA, ELENI — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: MARKOUTSA, ELENI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.