Investigating how COVID-19 affects the placenta during pregnancy
Spatiotemporal transcriptomics at the maternal-fetal interface in COVID placenta
['FUNDING_R21'] · LOUISIANA STATE UNIV HSC SHREVEPORT · NIH-10618958
This study is looking at how COVID-19 affects the placenta in pregnant women and how the body's natural defenses help protect the baby from the virus, so we can better understand how to keep both moms and their little ones safe.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOUISIANA STATE UNIV HSC SHREVEPORT (nih funded) |
| Locations | 1 site (SHREVEPORT, UNITED STATES) |
| Trial ID | NIH-10618958 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the effects of COVID-19 on the placenta in pregnant women. It examines how the innate immune system protects the developing fetus from the virus, particularly through the expression of specific immune molecules in placental tissues. By analyzing the maternal-fetal interface, the study aims to uncover the mechanisms that prevent vertical transmission of the virus and ensure fetal safety. The research employs advanced transcriptomic techniques to map gene expression patterns related to antiviral defense in the placenta.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who have tested positive for COVID-19.
Not a fit: Patients who are not pregnant or those who have not been infected with COVID-19 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of COVID-19 in pregnant women, potentially reducing maternal and neonatal complications.
How similar studies have performed: While there has been extensive research on COVID-19, the specific focus on placental defense mechanisms is relatively novel and has not been extensively tested.
Where this research is happening
SHREVEPORT, UNITED STATES
- LOUISIANA STATE UNIV HSC SHREVEPORT — SHREVEPORT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, YUPING — LOUISIANA STATE UNIV HSC SHREVEPORT
- Study coordinator: WANG, YUPING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.