Investigating how COVID-19 affects brain function and its relation to Alzheimer's disease.
Neuroprotective Potential of Vaccination Against SARS-CoV-2 in Nonhuman Primates
This study is looking at how COVID-19 might affect brain function and could be linked to Alzheimer's disease, using advanced imaging in monkeys to see how their brains change after vaccination and infection, which could help us understand the long-term effects on human brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10646617 on NIH RePORTER |
What this research studies
This research aims to explore the impact of COVID-19 on brain function and neurobiology, particularly focusing on changes that may relate to Alzheimer's disease. By using advanced imaging techniques, the study will assess brain alterations in nonhuman primates after vaccination and infection with SARS-CoV-2. The goal is to identify specific brain regions that may be more vulnerable to the effects of COVID-19 and to understand the potential long-term cognitive implications for humans. This research could provide insights into the neurological consequences of COVID-19 and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals who have experienced COVID-19 and exhibit cognitive deficits or are at risk for Alzheimer's disease.
Not a fit: Patients who have not been infected with COVID-19 or do not exhibit any cognitive symptoms may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of cognitive deficits associated with COVID-19 and Alzheimer's disease.
How similar studies have performed: Other studies have indicated significant neurological impacts of COVID-19, suggesting that this research builds on established findings rather than being entirely novel.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Daunais, James B — Wake Forest University Health Sciences
- Study coordinator: Daunais, James B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.