Investigating how cortisol affects the formation of tunnels in Hidradenitis suppurativa
The role of cortisol synthesis in pathogenesis of Hidradenitis suppurativa tunnels
This study is looking at how a hormone called cortisol affects the painful skin tunnels that people with Hidradenitis suppurativa (HS) experience, using a special 3D model to help find better treatments for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10980978 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cortisol synthesis in the development of unique tunnel formations associated with Hidradenitis suppurativa (HS), a painful skin condition. The team has created a 3D model that mimics the skin tunnels found in HS patients, allowing for a detailed examination of how cortisol and related pathways are altered in these areas. By analyzing tissue samples from patients, the researchers aim to uncover the mechanisms behind chronic inflammation and identify potential therapeutic targets. This innovative approach could lead to more effective treatments for HS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Hidradenitis suppurativa who experience tunnel formations.
Not a fit: Patients without Hidradenitis suppurativa or those who do not have tunnel formations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively target the underlying causes of Hidradenitis suppurativa tunnels, improving patients' quality of life.
How similar studies have performed: While the specific approach of using 3D models for HS tunnels is novel, similar methodologies have shown promise in other inflammatory conditions.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Tomic-Canic, Marjana — University of Miami School of Medicine
- Study coordinator: Tomic-Canic, Marjana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.