Investigating how cortisol affects the formation of tunnels in Hidradenitis suppurativa
Official title: The role of cortisol synthesis in pathogenesis of Hidradenitis suppurativa tunnels
Funded at University of Miami School of Medicine · NIH-10980978 · Data updated 2026-11-12
This study is looking at how a hormone called cortisol affects the painful skin tunnels that people with Hidradenitis suppurativa (HS) experience, using a special 3D model to help find better treatments for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 2, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $466,198 |
| NIH project number | 1R01AR083385-01A1 |
| Project ID | NIH-10980978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Hidradenitis suppurativa who experience tunnel formations.
✕Less likely to help
Patients without Hidradenitis suppurativa or those who do not have tunnel formations may not benefit from this research.
What this research studies
This research focuses on understanding the role of cortisol synthesis in the development of unique tunnel formations associated with Hidradenitis suppurativa (HS), a painful skin condition. The team has created a 3D model that mimics the skin tunnels found in HS patients, allowing for a detailed examination of how cortisol and related pathways are altered in these areas. By analyzing tissue samples from patients, the researchers aim to uncover the mechanisms behind chronic inflammation and identify potential therapeutic targets. This innovative approach could lead to more effective treatments for HS.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively target the underlying causes of Hidradenitis suppurativa tunnels, improving patients' quality of life.
How similar studies have gone: While the specific approach of using 3D models for HS tunnels is novel, similar methodologies have shown promise in other inflammatory conditions.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Tomic-Canic, Marjana — University of Miami School of Medicine
- Study coordinator: Tomic-Canic, Marjana
Related research
Other NIH-funded projects on the same topics.
-
Anti-CD38 immunotherapy for severe hidradenitis suppurativa
A new treatment using anti-CD38 therapy is being tested for people with severe hidradenitis suppurativa who have not responded to prior therapies.
-
Botulinum toxin blocks nerve signals to immune cells to treat hidradenitis suppurativa
This NIH grant tests a new approach to hidradenitis suppurativa by using botulinum toxin to interrupt nerve signals that may drive skin inflammation in patients.
-
Precision therapies for hidradenitis suppurativa using AI
A doctor-researcher team at UC San Francisco is using advanced computer methods to find personalized drug options to treat hidradenitis suppurativa.
-
Injectable Hydrogel for HS: a localized therapy to ease painful skin disease
A new baricitinib hydrogel is being developed to deliver pain relief and reduce inflammation directly in hidradenitis suppurativa (HS) lesions, potentially lowering systemic side effects.
-
Whole-genome sequencing to understand hidradenitis suppurativa in diverse groups
Researchers will study the genetic factors that contribute to hidradenitis suppurativa, especially in African American, Hispanic/Latino, and White patients, to better understand why some people are more affected.
-
Understanding the Genes Behind Hidradenitis Suppurativa in teens and young adults
A study to find genetic factors that contribute to hidradenitis suppurativa (HS), a painful skin condition that often starts in adolescence and affects many Black individuals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.