Investigating how corneal cells can help heal eye injuries from chemical toxins
Targeting Corneal Schwann cells to counteract against toxin injury
This study is looking at how a harmful chemical can hurt the eye's surface and how certain cells in the eye might help heal those injuries, with the goal of finding new treatments to protect and repair the eye for people affected by this kind of damage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11097267 on NIH RePORTER |
What this research studies
This research focuses on understanding the damage caused to the cornea by sulfur mustard, a chemical toxin that can lead to severe eye injuries. The study aims to explore the role of corneal Schwann cells, which support nerve regeneration, in healing these injuries. By analyzing molecular pathways and identifying potential drug targets, the researchers hope to develop new therapies that can protect and regenerate corneal nerves affected by such toxins. The approach includes using animal models to better understand the mechanisms of nerve degeneration and regeneration in the cornea.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced eye injuries due to chemical exposure, particularly those involving sulfur mustard.
Not a fit: Patients with eye injuries from non-chemical causes or those with pre-existing corneal conditions unrelated to toxin exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore corneal nerve function and alleviate pain for patients suffering from chemical-induced eye injuries.
How similar studies have performed: Previous research has shown that Schwann cells can effectively support nerve regeneration in other parts of the body, suggesting a promising avenue for similar success in corneal injuries.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Mohan, Royce — University of Connecticut Sch of Med/dnt
- Study coordinator: Mohan, Royce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.