Investigating how copper and heme complexes activate oxygen and nitric oxide
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes
This study is exploring how certain copper compounds work with oxygen and nitric oxide, which could help us learn more about how these processes affect health, potentially leading to better treatments for related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11010859 on NIH RePORTER |
What this research studies
This research focuses on understanding the chemical processes involving copper and heme coordination complexes, particularly how they activate molecular oxygen and nitric oxide. By designing and synthesizing synthetic models, the research aims to uncover the fundamental structures and mechanisms of these complexes. Patients may benefit from insights gained into the biochemical pathways that involve these elements, which could lead to advancements in treatments for diseases related to oxygen and nitric oxide processing. The methodology includes advanced spectroscopy and structural analysis to characterize the active sites of these complexes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with metabolic disorders or diseases linked to copper and heme processing.
Not a fit: Patients with conditions unrelated to copper or heme metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to oxygen and nitric oxide metabolism.
How similar studies have performed: Other research has shown promise in understanding similar biochemical processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Karlin, Kenneth D. — Johns Hopkins University
- Study coordinator: Karlin, Kenneth D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.