Investigating how Complex II of the electron transport chain affects skin development
Official title: Genetic and genomic analysis of electron transport chain Complex II functions in mammalian skin development
Funded at Northwestern University at Chicago · NIH-11066727 · Data updated 2026-11-12
This study is looking at how certain parts of the energy-making process in our cells affect skin growth and hair development, which could help us learn more about skin issues and find better treatments for them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $44,187 |
| NIH project number | 1F31AR085379-01 |
| Project ID | NIH-11066727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with skin development disorders or those interested in genetic factors affecting skin health.
✕Less likely to help
Patients with skin conditions unrelated to genetic or metabolic factors may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of Complex II in the electron transport chain and its impact on skin development. By using novel mouse models with specific deletions of key components of Complex I and II, the study aims to uncover how these complexes influence skin morphology and hair growth. The research will analyze the effects of these deletions on cellular signaling and tissue morphogenesis, which could provide insights into skin-related disorders. Patients may benefit from findings that improve understanding of skin development and potential treatments for skin conditions.
Why it matters
Potential benefit: If successful, this research could lead to new insights into skin development and potential therapies for skin disorders.
How similar studies have gone: Previous research has shown success in understanding mitochondrial functions in other contexts, but this specific focus on Complex II in skin development is relatively novel.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Stephens, Christopher M — Northwestern University at Chicago
- Study coordinator: Stephens, Christopher M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.