Investigating how complement receptor activation affects mixed dementia.
Official title: Role of Complement Receptor Activation in a Mixed Dementia Model
Funded at VA Greater Los Angeles Healthcare System · NIH-11098428 · Data updated 2026-11-12
This study is looking at how certain immune system signals might affect brain health in people with mixed dementia, which includes both Alzheimer's and blood vessel issues, using a special rat model to find new ways to help improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005919-03 |
| Project ID | NIH-11098428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with mixed dementia, particularly those exhibiting symptoms of both Alzheimer's disease and cerebrovascular disease.
✕Less likely to help
Patients with pure Alzheimer's disease or those without any signs of cerebrovascular disease may not benefit from this research.
What this research studies
This research explores the role of complement receptor activation in a model of mixed dementia, which combines Alzheimer's disease and cerebrovascular disease. Using a specially bred rat model that mimics the complexities of these conditions, the study aims to understand how hypertension and small vessel disease contribute to neuroinflammation and tau protein abnormalities. By examining these interactions, researchers hope to identify potential therapeutic targets that could improve treatment outcomes for patients with mixed dementia.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better address the complexities of mixed dementia, potentially improving patient outcomes.
How similar studies have gone: While the approach of using a mixed dementia model is relatively novel, previous studies have shown promise in understanding the interactions between Alzheimer's disease and cerebrovascular conditions.
Where this research is happening
-
VA Greater Los Angeles Healthcare System
Los Angeles, United States Active
Researchers
- Principal investigator: Frautschy, Sally Ann — VA Greater Los Angeles Healthcare System
- Study coordinator: Frautschy, Sally Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.