Investigating how complement activation affects preeclampsia during pregnancy
Evaluating role of complement activation induced signaling pathways in preeclampsia pathology using a novel complement activation-based mouse model
This study is looking at how a part of the immune system called complement activation might cause problems like high blood pressure and slow growth in babies during pregnancy, with the hope of finding new ways to help women with preeclampsia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10879076 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of complement activation in the development of preeclampsia, a serious pregnancy complication. By using a novel mouse model, researchers will explore how complement activation contributes to hypertension and fetal growth restriction in pregnant women. The study aims to identify the specific signaling pathways involved, which could lead to new therapeutic targets for managing preeclampsia. Patients may benefit from insights gained that could improve treatment options for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women at risk of developing preeclampsia or those diagnosed with the condition.
Not a fit: Patients who are not pregnant or those with pre-existing hypertension unrelated to pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risks associated with preeclampsia for pregnant women and their babies.
How similar studies have performed: Previous research has shown that targeting complement activation pathways can be effective in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Yallampalli, Chandrasekhar — Baylor College of Medicine
- Study coordinator: Yallampalli, Chandrasekhar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.