Investigating how combination adjuvants can enhance vaccine responses in children
Mechanistic Studies of Combination Adjuvants to Target B Cells in Vaccines
['FUNDING_U01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11036379
This study is looking at how two special ingredients in vaccines can work together to make them more effective for kids under 11, with the goal of creating a strong one-dose vaccine that protects them well and has fewer side effects.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11036379 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how two types of adjuvants, NKT cell and TLR7, work together to improve vaccine effectiveness, particularly for children under 11 years old. By studying these mechanisms, the researchers aim to create a vaccine that provides strong protection with just one dose. The approach includes evaluating how these adjuvants enhance immune responses in various immune cells and measuring the effectiveness of different combinations in animal models. This work could also help minimize potential side effects associated with vaccine adjuvants.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who may be at risk for acute autoimmune neuropathies.
Not a fit: Patients who are older than 11 years or those with chronic autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that require fewer doses and provide better protection against infections in young children.
How similar studies have performed: Previous research has shown promising results with similar adjuvant combinations, indicating potential for success in this area.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TEYTON, LUC — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: TEYTON, LUC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.