Investigating how collagen signaling affects protein production in bladder cancer metastasis
Official title: The non-canonical Collagen I-DDR1 signaling regulating protein synthesis during metastasis
Funded at Cedars-Sinai Medical Center · NIH-10997301 · Data updated 2026-11-12
This study is looking at how the surrounding environment of bladder cancer cells, especially a protein called collagen, affects how these cells make proteins when they are under stress, which could help us find new ways to stop the cancer from spreading.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 22, 2023 |
| Project end | December 21, 2026 |
| Funding year | 2025 |
| Award (this year) | $41,294 |
| NIH project number | 5F31CA278582-02 |
| Project ID | NIH-10997301 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with bladder cancer, particularly those experiencing advanced stages of the disease.
✕Less likely to help
Patients with non-cancerous conditions or those with early-stage bladder cancer may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how the tumor microenvironment, particularly collagen signaling, influences protein synthesis in bladder cancer cells during metastasis. The study aims to explore two specific mechanisms by which collagen interacts with Discoidin Domain Receptor 1 (DDR1) to regulate protein production, especially under nutrient-deprived conditions. By examining these processes, the research seeks to uncover how cancer cells adapt to survive and spread, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about how to target these signaling pathways to inhibit cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent bladder cancer from spreading by targeting the mechanisms of protein synthesis regulation.
How similar studies have gone: While the specific mechanisms being investigated are novel, previous studies have shown success in targeting similar signaling pathways in cancer treatment.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Alonzo, Mark E. — Cedars-Sinai Medical Center
- Study coordinator: Alonzo, Mark E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.