Investigating how collagen changes contribute to lung scarring in older adults
Collagen Oxidation, Myofibroblast Activation and Age-Associated Pulmonary Fibrosis
This study is looking at how changes in certain proteins in the lungs might affect the progression of idiopathic pulmonary fibrosis (IPF) in older adults, and it hopes to find new ways to help improve lung health for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10863939 on NIH RePORTER |
What this research studies
This research focuses on idiopathic pulmonary fibrosis (IPF), a serious lung disease that leads to scarring and reduced lung function, particularly in older adults. The study examines how oxidative changes in proteins, specifically collagen, affect the progression of IPF. By understanding the mechanisms of protein oxidation and its impact on lung tissue, the research aims to identify potential therapeutic targets to improve lung health. Patients may be involved in providing lung tissue samples or participating in assessments to help elucidate these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with idiopathic pulmonary fibrosis.
Not a fit: Patients with other forms of lung disease or those without a diagnosis of pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or reverse lung scarring in patients with IPF.
How similar studies have performed: Previous research has shown promising results in understanding the role of oxidative stress in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Janssen-Heininger, Yvonne M. W. — University of Vermont & St Agric College
- Study coordinator: Janssen-Heininger, Yvonne M. W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.