Investigating how collagen affects the removal of amyloid fibrils in the body
Official title: Addressing Collagen Mediated Protection of Systemic Amyloid Fibrils
Funded at University of Tennessee Health Sci Ctr · NIH-10940420 · Data updated 2026-11-12
This study is looking into why the body has trouble getting rid of harmful protein clumps that can cause serious health problems in people with systemic amyloidosis, and it hopes to find ways to help the body clear these clumps more effectively, which could lead to better health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $348,460 |
| NIH project number | 1R01AI184456-01 |
| Project ID | NIH-10940420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with systemic amyloidosis or related conditions characterized by amyloid fibril accumulation.
✕Less likely to help
Patients with non-amyloid related conditions or those who do not have systemic amyloidosis may not benefit from this research.
What this research studies
This research focuses on understanding systemic amyloidoses, which are disorders where proteins misfold and form harmful amyloid fibrils that accumulate in organs, leading to serious health issues. The study aims to explore why the body struggles to eliminate these fibrils and how collagen may play a role in this process. By examining the interactions between collagen and amyloid fibrils, the researchers hope to develop new strategies that could enhance the body's ability to clear these deposits, potentially improving patient outcomes. The approach includes both understanding the biological mechanisms involved and exploring therapeutic interventions that could stimulate natural clearance processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help the body naturally remove harmful amyloid deposits, improving health outcomes for patients with systemic amyloidoses.
How similar studies have gone: While there have been various approaches to treating amyloidosis, this specific investigation into collagen's role in amyloid clearance is novel and has not been extensively tested.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Jackson, Joseph Wilson — University of Tennessee Health Sci Ctr
- Study coordinator: Jackson, Joseph Wilson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.