Investigating how collagen affects the growth and spread of aggressive brain tumors.
The Role of Collagen and its Signaling Mechanisms in Glioma Progression and Invasion.
This study is looking at how a protein called collagen affects the growth and spread of aggressive brain tumors called gliomas, with the hope of finding better treatments for patients dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11001509 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of collagen, specifically Collagen1A1, in the progression and invasion of malignant gliomas, which are highly aggressive brain tumors. By analyzing cellular and molecular data, the study aims to uncover how collagen influences tumor behavior and patient survival. The research utilizes advanced techniques such as single-cell RNA sequencing to identify specific cell types within gliomas that express high levels of collagen. The ultimate goal is to provide insights that could lead to improved treatment strategies for patients with gliomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with malignant gliomas who are undergoing treatment or have recently had surgery.
Not a fit: Patients with non-glioma brain tumors or those who are not currently receiving treatment for their tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance survival and quality of life for patients with gliomas.
How similar studies have performed: Previous research has shown that targeting collagen in other types of tumors has potential therapeutic benefits, suggesting that this approach may also be effective for gliomas.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Lowenstein, Pedro R. — University of Michigan at Ann Arbor
- Study coordinator: Lowenstein, Pedro R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.