Investigating how cognitive behavioral therapy can improve sleep and cognitive function in older adults with insomnia to prevent Alzheimer's disease.
Official title: Primary Prevention of Alzheimer's disease: Examining the effects of cognitive behavioral therapy on cognitive function and amyloid-beta in older adults with symptoms of insomnia
Funded at University of Kansas Medical Center · NIH-10689865 · Data updated 2026-11-12
This study is looking at how a special therapy for sleep problems can help older adults think better and possibly slow down memory loss related to Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | February 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $699,698 |
| NIH project number | 5R01AG058530-05 |
| Project ID | NIH-10689865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who experience symptoms of insomnia and are at risk for cognitive decline.
✕Less likely to help
Patients who do not have insomnia or significant cognitive concerns may not benefit from this research.
What this research studies
This research focuses on the impact of cognitive behavioral therapy for insomnia (CBT-I) on cognitive function in older adults experiencing sleep disturbances. It aims to determine whether improving sleep quality through CBT-I can slow cognitive decline and potentially delay the onset of Alzheimer's disease. The study will involve older adults with insomnia, assessing changes in their cognitive abilities and amyloid-beta levels over time. By targeting sleep issues, this research seeks to explore a novel approach to Alzheimer's disease prevention.
Why it matters
Potential benefit: If successful, this research could provide a new method for preventing Alzheimer's disease by improving sleep quality in older adults.
How similar studies have gone: While lifestyle interventions for Alzheimer's prevention have been explored, the specific use of CBT-I for this purpose is a novel approach that has not been extensively tested.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Siengsukon, Catherine F — University of Kansas Medical Center
- Study coordinator: Siengsukon, Catherine F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.