Investigating how claudin proteins affect ion channels in the gut
Structure, function, and modulation of claudin cation channels in the GI tract
This study is looking at how certain proteins in your gut help control the movement of important substances, which could lead to better treatments for conditions like inflammatory bowel disease and celiac disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10898067 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of claudin proteins in the gastrointestinal tract, particularly how they form channels that regulate the movement of ions and small molecules across epithelial cells. By using advanced techniques like patch clamping and computer modeling, the researchers aim to uncover how these proteins contribute to conditions such as inflammatory bowel disease and celiac disease. The study will also explore potential new treatments by identifying blockers that can inhibit these channels, which may help restore proper gut function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from inflammatory bowel disease, celiac disease, or other gastrointestinal disorders related to epithelial barrier dysfunction.
Not a fit: Patients with gastrointestinal conditions unrelated to epithelial barrier dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for gastrointestinal diseases that improve nutrient absorption and reduce symptoms like diarrhea.
How similar studies have performed: Other research has shown promise in targeting tight junction proteins for therapeutic purposes, indicating that this approach could be effective.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Weber, Christopher — University of Chicago
- Study coordinator: Weber, Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.