Investigating how circular RNAs interact with proteins to affect Alzheimer's disease
Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology
This study is looking at how certain molecules in our cells might play a role in Alzheimer's disease, with the hope of finding new ways to help treat it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11126150 on NIH RePORTER |
What this research studies
This research explores the role of circular RNAs (circRNAs) and RNA-binding proteins (RBPs) in Alzheimer's disease and related dementias. By examining how these molecules interact, the study aims to uncover new mechanisms that contribute to neurodegeneration. The approach involves analyzing genetic variants and their effects on circRNA production and function, particularly in neuronal tissues. Understanding these interactions could reveal novel targets for therapeutic intervention in Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and related dementias.
How similar studies have performed: While the investigation of circRNAs in neurodegeneration is a relatively novel area, preliminary studies have shown promising results in understanding their role in other neurological conditions.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Zhang, Xiaoling — Boston University Medical Campus
- Study coordinator: Zhang, Xiaoling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.