Investigating how circular RNAs affect protein changes in Alzheimer's disease
Official title: Changes in protein glycosylation due to translation of mannosidases encoded by circular RNAs
Funded at University of Kentucky · NIH-10885423 · Data updated 2026-11-12
This study is looking at how certain circular RNAs might affect the way proteins are modified in Alzheimer's disease, which could help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $420,750 |
| NIH project number | 1R21AG087332-01 |
| Project ID | NIH-10885423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how circular RNAs, specifically those related to mannosidases, influence protein glycosylation in the context of Alzheimer's disease. The study examines the expression of two specific circular RNAs, MAN2A1 and MAN1A2, and their role in the progression of Alzheimer's. By analyzing how these circular RNAs are translated and how they affect protein modifications, the research aims to uncover new molecular mechanisms that could be linked to disease severity. Patients may benefit from insights gained into the biochemical changes associated with Alzheimer's, potentially leading to new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing or treating Alzheimer's disease by targeting specific molecular changes.
How similar studies have gone: While the specific approach of studying circular RNAs in this context is relatively novel, similar research has shown promise in understanding RNA editing and its implications in neurodegenerative diseases.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Stamm, Stefan — University of Kentucky
- Study coordinator: Stamm, Stefan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.