Investigating how circular RNAs affect protein changes in Alzheimer's disease
Changes in protein glycosylation due to translation of mannosidases encoded by circular RNAs
This study is looking at how certain circular RNAs might affect the way proteins are modified in Alzheimer's disease, which could help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10885423 on NIH RePORTER |
What this research studies
This research focuses on understanding how circular RNAs, specifically those related to mannosidases, influence protein glycosylation in the context of Alzheimer's disease. The study examines the expression of two specific circular RNAs, MAN2A1 and MAN1A2, and their role in the progression of Alzheimer's. By analyzing how these circular RNAs are translated and how they affect protein modifications, the research aims to uncover new molecular mechanisms that could be linked to disease severity. Patients may benefit from insights gained into the biochemical changes associated with Alzheimer's, potentially leading to new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing or treating Alzheimer's disease by targeting specific molecular changes.
How similar studies have performed: While the specific approach of studying circular RNAs in this context is relatively novel, similar research has shown promise in understanding RNA editing and its implications in neurodegenerative diseases.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Stamm, Stefan — University of Kentucky
- Study coordinator: Stamm, Stefan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.