Investigating how circular RNAs affect drug metabolism in children
Circular RNA regulators of common drug-eliminating genes
This study is looking at how special molecules called circular RNAs affect how children's bodies process medications, especially since kids can be more sensitive to drug side effects, and it aims to help make medications safer for them as they grow up.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10684130 on NIH RePORTER |
What this research studies
This research focuses on understanding how circular RNAs influence the expression of genes responsible for drug metabolism in children, who are particularly vulnerable to drug toxicities. The study examines the differences in gene expression between the liver and duodenum, two key organs involved in drug processing, and how these differences change with age. By characterizing the sequences and functions of these circular RNAs, the research aims to uncover their role in regulating drug-eliminating genes, which could lead to safer medication use in pediatric populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who may be prescribed medications that require careful monitoring for potential toxicity.
Not a fit: Patients outside the age range of 0-11 years or those not taking medications metabolized by the studied enzymes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug safety and efficacy for children by tailoring medication based on their unique metabolic profiles.
How similar studies have performed: While the role of circular RNAs in gene regulation is a growing field, this specific approach to studying their impact on drug metabolism in children is relatively novel.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Yan, Bingfang — University of Cincinnati
- Study coordinator: Yan, Bingfang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.