Investigating how circadian rhythms affect liver cancer progression from fatty liver disease
3D Circadian Enhancer-Promoter Interactions Mediated by ESRRG in NAFLD-to-HCC Progression
['FUNDING_R37'] · BAYLOR COLLEGE OF MEDICINE · NIH-11028722
This study is looking at how our body's natural clock affects the progression of nonalcoholic fatty liver disease to liver cancer, hoping to find new ways to improve treatment for patients with NAFLD.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11028722 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between circadian rhythms and the progression of nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). It focuses on understanding how disruptions in these rhythms may contribute to cancer development. By analyzing gene interactions and the role of specific transcription factors, the study aims to uncover new insights into the mechanisms behind this progression. Patients with NAFLD may benefit from findings that could lead to improved treatment strategies based on timing and circadian biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with nonalcoholic fatty liver disease (NAFLD) or its more severe form, nonalcoholic steatohepatitis (NASH).
Not a fit: Patients without any liver disease or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that optimize treatment timing for patients with liver disease, potentially reducing the risk of developing liver cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUAN, DONGYIN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: GUAN, DONGYIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.