Investigating how cilia in blood vessels affect Alzheimer's disease
Official title: Cerebrovascular endothelial cilia in the pathogenesis and therapy of Alzheimer's disease
Funded at University of Toledo Health Sci Campus · NIH-10772077 · Data updated 2026-11-12
This study is looking at how tiny structures on blood vessel cells, called primary cilia, might affect Alzheimer's disease and could help find new treatments for it, especially for those dealing with high blood pressure and memory problems.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $151,775 |
| NIH project number | 5R03AG080418-02 |
| Project ID | NIH-10772077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline associated with hypertension.
✕Less likely to help
Patients with Alzheimer's disease who do not have hypertension or related vascular issues may not benefit from this research.
What this research studies
This research explores the role of primary cilia, tiny organelles on blood vessel cells, in the development and treatment of Alzheimer's disease. It focuses on how these cilia sense signals and fluid flow, and how their dysfunction can lead to issues like high blood pressure and cognitive decline. By understanding the connection between cilia, certain receptors, and blood pressure, the research aims to uncover new therapeutic targets for Alzheimer's. Patients may benefit from insights that could lead to innovative treatments for this condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have gone: While the specific connection between cilia and Alzheimer's has not been extensively studied, related research on cilia dysfunction and cognitive impairment suggests potential for significant findings.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Aboualaiwi, Wissam — University of Toledo Health Sci Campus
- Study coordinator: Aboualaiwi, Wissam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.