Investigating how cilia affect blood vessel health in the brain
Cilia as a biomarker of CNS vascular health
This study is looking at how tiny hair-like structures in the brain help keep blood vessels healthy, especially for people with sickle cell disease, to see how problems with blood flow might affect brain protection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10914078 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cilia, tiny hair-like structures on brain endothelial cells, in maintaining the health of blood vessels in the brain. By studying how these cilia interact with blood flow and red blood cells, researchers aim to uncover their importance in the function of the blood-brain barrier, which protects the brain from harmful substances. The project involves advanced models, including human stem cells and animal studies, to explore how disruptions in blood flow may lead to the loss of cilia and impact brain health, particularly in patients with sickle cell disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with sickle cell disease or those experiencing issues related to blood flow in the brain.
Not a fit: Patients without any vascular health issues or those not affected by sickle cell disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating brain injuries related to blood flow disruptions.
How similar studies have performed: Previous research has shown promising results in understanding the role of cilia in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Ramchandran, Ramani — Medical College of Wisconsin
- Study coordinator: Ramchandran, Ramani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.