Investigating how cigarette smoke affects small airways through immune cells
Interstitial macrophages in cigarette smoke-induced small airway remodeling
This study is looking at how certain immune cells are affected by cigarette smoke and how they might contribute to damage in the lungs, with the hope of finding new ways to help smokers and improve treatments for lung diseases like COPD.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-11004260 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific immune cells, known as interstitial macrophages, in the damage caused to small airways by cigarette smoke. The principal investigator, Dr. Patrick Hume, aims to identify potential targets for therapies that could prevent or repair airway damage in smokers. The study involves advanced techniques to analyze the biological processes at play in chronic obstructive pulmonary disease (COPD) and aims to translate these findings into clinical applications. Patients may benefit from insights that could lead to new treatments for airway diseases related to smoking.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cigarette smoking who are experiencing symptoms of airway disease or COPD.
Not a fit: Patients who have never smoked or those with non-respiratory conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent or repair airway damage in smokers, improving lung health.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in COPD, suggesting that this approach could yield valuable insights.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Hume, Patrick Scott — National Jewish Health
- Study coordinator: Hume, Patrick Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.