Investigating how chronic stress influences habit formation in the brain
Do opposing amygdala-striatal pathways enable chronic stress to promote habit formation?
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11192905
This study looks at how long-term stress affects the brain's ability to create habits, especially in areas linked to emotions and decision-making, to help people understand how stress might play a role in issues like anxiety, depression, and addiction.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11192905 on ClinicalTrials.gov |
What this research studies
This research explores the impact of chronic stress on the brain's ability to form habits, particularly focusing on the amygdala and striatal pathways. By examining how these neural circuits are affected by stress, the study aims to understand the mechanisms that lead to compulsive behaviors and decision-making difficulties. Patients may benefit from insights into how stress contributes to various mental health conditions, including anxiety, depression, and substance use disorders. The research employs advanced techniques to analyze brain activity and behavior in response to stress.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing chronic stress or those with mental health conditions such as anxiety, depression, or substance use disorders.
Not a fit: Patients who do not experience chronic stress or have no history of mental health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for mental health conditions exacerbated by chronic stress.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between stress and habit formation, indicating that this approach has potential for significant insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WASSUM, KATE M — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: WASSUM, KATE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.