Investigating how chronic stress affects the immune system and heart health
Official title: Preclinical imaging of immune responses to chronic stress
Funded at Icahn School of Medicine at Mount Sinai · NIH-10878890 · Data updated 2026-11-12
This study is looking at how short-term and long-term stress affects your immune system and the buildup of plaque in your arteries, which can lead to heart problems, to help us understand how stress might impact your heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $626,740 |
| NIH project number | 5R01HL169500-02 |
| Project ID | NIH-10878890 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing chronic stress or those at risk for cardiovascular diseases.
✕Less likely to help
Patients who do not experience stress-related health issues or have pre-existing severe cardiovascular conditions may not benefit from this research.
What this research studies
This research explores the impact of both acute and chronic stress on the immune system and the development of atherosclerosis, a condition that can lead to heart disease. Using advanced non-invasive imaging techniques, the study aims to understand how stress influences immune cell behavior and inflammation in blood vessels. By examining the biological responses triggered by stress, researchers hope to uncover important links between psychosocial stress and cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cardiovascular diseases related to stress.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between stress and cardiovascular health, indicating that this approach has potential for significant insights.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Van Leent, Mandy Maria Theresia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Van Leent, Mandy Maria Theresia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.