Investigating how chronic stress affects behavior and brain function in mice
Digital behavioral phenotyping and multi-region electrophysiology to determine behavioral and neural network changes underlying the stress response in mice
This study is looking at how long-term stress affects the behavior and brain function of mice, which could help us understand similar issues in people with depression, and it will track different behaviors and brain changes to find clues about how stress impacts us.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11045085 on NIH RePORTER |
What this research studies
This research explores the impact of chronic psychological stress on behavior and brain function in mice, which can provide insights relevant to human mental health conditions like major depressive disorder. Using a novel system called the 'Digital Homecage', researchers will monitor over 50 behavioral measures in mice subjected to chronic unpredictable stress. The study aims to understand how stress influences various behaviors and physiological changes over time, and to identify potential biomarkers for stress responses. Additionally, the research will examine the electrophysiological changes in the brain associated with chronic stress.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research are individuals suffering from stress-related conditions such as major depressive disorder or anxiety disorders.
Not a fit: Patients with acute stress responses or those not experiencing chronic psychological stress may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for stress-related psychiatric disorders in humans.
How similar studies have performed: Previous research has shown promising results in understanding stress responses in animal models, indicating that this approach may yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Watson, Brendon O — University of Michigan at Ann Arbor
- Study coordinator: Watson, Brendon O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.