Investigating how chronic low oxygen levels affect depression risk in older women.
Official title: Sex-based study of chronic hypoxia-related vulnerability to depression: age effects
Funded at University of Utah · NIH-11187100 · Data updated 2026-11-12
This study is looking at how low oxygen levels might affect the risk of depression in older women, especially those over 65, to find new ways to help improve their mental health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $192,500 |
| NIH project number | 5R21AG086520-02 |
| Project ID | NIH-11187100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women aged 65 and older who are experiencing symptoms of depression or are at risk for developing major depressive disorder.
✕Less likely to help
Patients under the age of 65 or those who do not have a history of depression may not benefit from this research.
What this research studies
This research explores the relationship between chronic low oxygen levels and the risk of major depressive disorder (MDD) in older adults, particularly focusing on women over 65. It utilizes a novel animal model to simulate conditions of chronic hypoxia, which occurs at high altitudes, to observe its effects on mental health. The study aims to understand how biological factors, such as inflammation and cognitive decline, interact with environmental conditions to influence depression risk. By examining these interactions, the research seeks to identify potential new treatment strategies for those affected by depression in later life.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for older women suffering from depression, particularly those living in high-altitude areas.
How similar studies have gone: Previous research has indicated that environmental factors like altitude can significantly impact mental health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Kanekar, Shami — University of Utah
- Study coordinator: Kanekar, Shami
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.