Investigating how chronic kidney disease affects heart and muscle health
Official title: Chronic Kidney Disease-Induced Defects Initiated by SIRPα
Funded at Michael E Debakey VA Medical Center · NIH-10867302 · Data updated 2026-11-12
This study is looking at how chronic kidney disease affects your heart and muscles, especially focusing on a protein called SIRPα, to help find better treatments for people dealing with heart problems caused by kidney issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michael E Debakey VA Medical Center NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01BX005792-02 |
| Project ID | NIH-10867302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with chronic kidney disease.
✕Less likely to help
Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
What this research studies
This research focuses on understanding the effects of chronic kidney disease (CKD) on heart and muscle health, particularly how a protein called SIRPα contributes to these changes. The study aims to uncover the molecular mechanisms behind CKD-induced cardiomyopathy, which is a condition where the heart muscle becomes weakened due to kidney issues. By examining the role of SIRPα in both skeletal muscles and the heart, the research seeks to clarify how CKD leads to insulin resistance and changes in heart size. This could help identify new treatment strategies for patients suffering from CKD and its complications.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with chronic kidney disease, potentially reducing their risk of heart disease and improving overall health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of proteins like SIRPα in chronic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Michael E Debakey VA Medical Center
Houston, United States Active
Researchers
- Principal investigator: Thomas, Sandhya S — Michael E Debakey VA Medical Center
- Study coordinator: Thomas, Sandhya S
Related research
Other NIH-funded projects on the same topics.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
-
Boosting self-care and physical activity for older adults with chronic kidney disease
This program helps older adults with chronic kidney disease build the skills, confidence, and motivation to be more physically active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.