Investigating how chronic kidney disease affects heart and muscle health
Chronic Kidney Disease-Induced Defects Initiated by SIRPα
This study is looking at how chronic kidney disease affects your heart and muscles, especially focusing on a protein called SIRPα, to help find better treatments for people dealing with heart problems caused by kidney issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michael E Debakey VA Medical Center NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10867302 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of chronic kidney disease (CKD) on heart and muscle health, particularly how a protein called SIRPα contributes to these changes. The study aims to uncover the molecular mechanisms behind CKD-induced cardiomyopathy, which is a condition where the heart muscle becomes weakened due to kidney issues. By examining the role of SIRPα in both skeletal muscles and the heart, the research seeks to clarify how CKD leads to insulin resistance and changes in heart size. This could help identify new treatment strategies for patients suffering from CKD and its complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with chronic kidney disease.
Not a fit: Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with chronic kidney disease, potentially reducing their risk of heart disease and improving overall health outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of proteins like SIRPα in chronic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Michael E Debakey VA Medical Center — Houston, United States (Active)
Researchers
- Principal investigator: Thomas, Sandhya S — Michael E Debakey VA Medical Center
- Study coordinator: Thomas, Sandhya S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.