Investigating how chronic inflammation in the prostate may lead to aggressive cancer.
Prostate inflammatory lesions as a proving ground for development of aggressive prostate cancer
This study is looking at how long-term inflammation in the prostate might lead to more serious prostate cancer, and it’s for anyone interested in understanding how lifestyle and other factors play a role in this process, with the hope of finding new ways to treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10918237 on NIH RePORTER |
What this research studies
This research explores the connection between chronic inflammation in the prostate and the development of aggressive prostate cancer. It examines how lifestyle, microbial, and environmental factors contribute to this inflammation and the paradox of immune responses in cancer. The study involves analyzing prostate tissue samples to understand the immune environment and the mechanisms that allow cancer cells to evade immune detection. By identifying these processes, the research aims to uncover potential targets for new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are older men with chronic prostate inflammation or at risk for prostate cancer.
Not a fit: Patients with non-inflammatory prostate conditions or those without a risk of prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for aggressive prostate cancer.
How similar studies have performed: Previous research has shown that understanding the immune environment in tumors can lead to breakthroughs in cancer treatment, suggesting this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: De Marzo, Angelo Michael — Johns Hopkins University
- Study coordinator: De Marzo, Angelo Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.