Investigating how chronic inflammation affects breast cancer development
Official title: A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development
Funded at Brigham and Women's Hospital · NIH-11021056 · Data updated 2026-11-12
This study is looking at how long-term inflammation and what we eat can affect the risk of developing aggressive breast cancer, especially in women with certain types of tumors, to help find better ways to prevent cancer through diet and lifestyle changes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $164,570 |
| NIH project number | 5K99CA286891-02 |
| Project ID | NIH-11021056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women with a history of chronic inflammation or those at high risk for aggressive breast cancer subtypes.
✕Less likely to help
Patients with non-aggressive forms of breast cancer or those without chronic inflammation may not benefit from this research.
What this research studies
This research aims to explore the connection between chronic inflammation and the development of aggressive forms of breast cancer by integrating dietary and lifestyle factors with advanced multi-omics data. Researchers will analyze data from the Nurses’ Health Study to identify how pro-inflammatory diets may increase breast cancer risk, particularly for estrogen receptor negative tumors. By combining various biological data and advanced statistical techniques, the study seeks to uncover the biological pathways that contribute to breast cancer etiology and enhance precision nutrition strategies for cancer prevention.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations and preventive strategies for breast cancer, particularly for high-risk individuals.
How similar studies have gone: Previous research has shown promising results in understanding the role of diet and inflammation in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Romanos-Nanclares, Andrea — Brigham and Women's Hospital
- Study coordinator: Romanos-Nanclares, Andrea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.