Investigating how chronic alcohol use affects brain health and Alzheimer's disease.
Chronic alcohol-induced mitochondrial oxidant stress and Alzheimer's related pathogenesis
This study is looking at how drinking a lot of alcohol might speed up the development of Alzheimer's disease by affecting brain cells, and it hopes to find new ways to help people who are at risk because of their drinking habits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10861892 on NIH RePORTER |
What this research studies
This research explores the connection between chronic alcohol consumption and the development of Alzheimer's disease (AD). It focuses on how heavy drinking may lead to mitochondrial stress in brain cells, particularly in neurons that produce norepinephrine. By examining the biological mechanisms involved, the study aims to understand how alcohol abuse accelerates the progression of AD. Patients may benefit from insights that could lead to new prevention or treatment strategies for those at risk of developing AD due to alcohol use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of chronic alcohol consumption who are concerned about their risk of developing Alzheimer's disease.
Not a fit: Patients who do not consume alcohol and have no risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into preventing or slowing the progression of Alzheimer's disease in individuals with a history of alcohol abuse.
How similar studies have performed: Previous research has indicated a link between alcohol abuse and increased risk of neurodegenerative diseases, suggesting that this study builds on established findings rather than exploring a completely novel area.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Graves, Steven Michael — University of Minnesota
- Study coordinator: Graves, Steven Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.