Investigating how chromosomes behave during the formation of sperm cells.
Development of a lacO/lacI based fluorescence reporter-operator system to study chromosome dynamics and double-strand break repair in mouse meiosis.
['FUNDING_R01'] · OKLAHOMA MEDICAL RESEARCH FOUNDATION · NIH-11031360
This study is looking at how mistakes happen with chromosomes when sperm cells are made, which can lead to conditions like Down's syndrome, and it aims to find ways to help ensure healthy sperm production.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA MEDICAL RESEARCH FOUNDATION (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11031360 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the processes that lead to chromosome errors during the formation of sperm cells, which can result in conditions like Down's syndrome. By using a specialized fluorescence system, researchers will observe how chromosomes move and interact during meiosis in mice. The study aims to identify the mechanisms that ensure proper chromosome segregation, which is crucial for producing healthy gametes. Insights gained from this research could lead to better strategies for predicting and preventing chromosome-related disorders in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or couples experiencing recurrent pregnancy loss or those with a history of chromosomal disorders in their family.
Not a fit: Patients who are not planning to conceive or those without a history of chromosomal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help develop methods to reduce the risk of pregnancy loss and genetic disorders caused by aneuploidy.
How similar studies have performed: Other research has shown promise in understanding chromosome dynamics, but this specific approach using the fluorescence reporter-operator system is relatively novel.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA MEDICAL RESEARCH FOUNDATION — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEZZA, ROBERTO JOSE — OKLAHOMA MEDICAL RESEARCH FOUNDATION
- Study coordinator: PEZZA, ROBERTO JOSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer/testis antigen 35