Investigating how chromosomes behave during the formation of sperm cells.
Official title: Development of a lacO/lacI based fluorescence reporter-operator system to study chromosome dynamics and double-strand break repair in mouse meiosis.
Funded at Oklahoma Medical Research Foundation · NIH-11031360 · Data updated 2026-11-12
This study is looking at how mistakes happen with chromosomes when sperm cells are made, which can lead to conditions like Down's syndrome, and it aims to find ways to help ensure healthy sperm production.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 10, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $366,575 |
| NIH project number | 5R01HD110990-03 |
| Project ID | NIH-11031360 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals or couples experiencing recurrent pregnancy loss or those with a history of chromosomal disorders in their family.
✕Less likely to help
Patients who are not planning to conceive or those without a history of chromosomal issues may not benefit from this research.
What this research studies
This research focuses on understanding the processes that lead to chromosome errors during the formation of sperm cells, which can result in conditions like Down's syndrome. By using a specialized fluorescence system, researchers will observe how chromosomes move and interact during meiosis in mice. The study aims to identify the mechanisms that ensure proper chromosome segregation, which is crucial for producing healthy gametes. Insights gained from this research could lead to better strategies for predicting and preventing chromosome-related disorders in humans.
Why it matters
Potential benefit: If successful, this research could help develop methods to reduce the risk of pregnancy loss and genetic disorders caused by aneuploidy.
How similar studies have gone: Other research has shown promise in understanding chromosome dynamics, but this specific approach using the fluorescence reporter-operator system is relatively novel.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Pezza, Roberto Jose — Oklahoma Medical Research Foundation
- Study coordinator: Pezza, Roberto Jose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.