Investigating how chromatin structure affects gene expression in living cells
Live-cell multiplex super-resolution imaging of chromatin state transitions
This study is looking at how the 3D shape of DNA in our cells affects how genes are turned on and off, using special imaging techniques to see these changes in real-time, which could help us understand important processes in health and disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10902108 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between the 3D structure of chromatin and the regulation of gene expression in cells. By developing advanced live-cell imaging technologies, the researchers aim to observe how chromatin changes over time and how these changes influence cellular functions. The approach involves using super-resolution microscopy to visualize chromatin dynamics at a single-cell level, allowing for a detailed analysis of cellular processes that are crucial for development and disease. This innovative methodology could provide insights into the mechanisms of gene regulation and epigenetic control.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to chromatin structure and gene regulation, such as certain cancers or genetic disorders.
Not a fit: Patients with stable, non-genetic conditions that do not involve chromatin dynamics or gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may improve treatments for various diseases.
How similar studies have performed: Previous research has shown promising results in using advanced imaging techniques to study cellular processes, indicating that this approach has the potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Bintu, Lacramioara — Stanford University
- Study coordinator: Bintu, Lacramioara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.