Investigating how chromatin remodeling affects bladder cancer development
Transcriptional-translational conflict in bladder epithelial homeostasis and cancer
This study is looking at how changes in certain genes and proteins in bladder cells might lead to bladder cancer, and it hopes to find ways to help patients by restoring normal protein production in tumors that have a specific gene problem.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10996169 on NIH RePORTER |
What this research studies
This research explores the relationship between chromatin remodeling and protein synthesis in bladder epithelial cells, particularly focusing on the role of the ARID1A gene. It aims to understand how disruptions in these processes can lead to bladder cancer. By using both human and mouse models, the researchers will examine how restoring protein synthesis can potentially reverse cancer progression in ARID1A deficient tumors. This work could provide insights into new therapeutic strategies for bladder cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with bladder cancer, particularly those with ARID1A deficiencies.
Not a fit: Patients without bladder cancer or those whose tumors do not involve ARID1A may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that target the mechanisms of bladder cancer progression.
How similar studies have performed: Other research has shown promising results in targeting chromatin remodeling and protein synthesis in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Hsieh, Andrew Caleb — Fred Hutchinson Cancer Center
- Study coordinator: Hsieh, Andrew Caleb
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.