Investigating how chromatin remodeling affects bladder cancer development
Official title: Transcriptional-translational conflict in bladder epithelial homeostasis and cancer
Funded at Fred Hutchinson Cancer Center · NIH-10996169 · Data updated 2026-11-12
This study is looking at how changes in certain genes and proteins in bladder cells might lead to bladder cancer, and it hopes to find ways to help patients by restoring normal protein production in tumors that have a specific gene problem.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $569,061 |
| NIH project number | 5R01CA276308-03 |
| Project ID | NIH-10996169 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with bladder cancer, particularly those with ARID1A deficiencies.
✕Less likely to help
Patients without bladder cancer or those whose tumors do not involve ARID1A may not benefit from this research.
What this research studies
This research explores the relationship between chromatin remodeling and protein synthesis in bladder epithelial cells, particularly focusing on the role of the ARID1A gene. It aims to understand how disruptions in these processes can lead to bladder cancer. By using both human and mouse models, the researchers will examine how restoring protein synthesis can potentially reverse cancer progression in ARID1A deficient tumors. This work could provide insights into new therapeutic strategies for bladder cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that target the mechanisms of bladder cancer progression.
How similar studies have gone: Other research has shown promising results in targeting chromatin remodeling and protein synthesis in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Hsieh, Andrew Caleb — Fred Hutchinson Cancer Center
- Study coordinator: Hsieh, Andrew Caleb
Related research
Other NIH-funded projects on the same topics.
-
How brain glia prune neuron fragments in a worm model
Researchers study how brain support cells called glia remove pieces of living neurons in a tiny worm to learn about brain aging and diseases like Alzheimer's.
-
Understanding and Targeting Lineage Plasticity in Prostate Cancer with Genomic-Based Neoadjuvant Therapy
A broad research program at Fred Hutchinson Cancer Center is exploring how aggressive prostate cancers change their cell states in response to therapy and how to block these changes.
-
Personalized cancer drug testing on patient tumor cells
Aiming to test many FDA-approved cancer drugs on a patient’s own tumor cells to identify effective options when standard therapies fail.
-
MOSAAIC: Using health records to track heart disease in Asian American Communities
A big, dedicated effort is testing whether electronic health records can more quickly and accurately track heart and blood vessel problems in Asian American populations.
-
Targeting gut microbes to prevent progression to multiple myeloma
Researchers are testing how specific gut bacteria might trigger immune changes linked to early blood cancer stages and whether targeting these microbes could help prevent progression to multiple myeloma.
-
eDyNAmiC: Understanding extrachromosomal DNA in cancer and how it drives aggressiveness
A cancer research project at Fred Hutchinson Cancer Center is studying abnormal circular DNA pieces (ecDNA) that help cancers grow and resist treatment, with the aim of finding ways to help patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.