Investigating how chromatin remodelers and histone modifiers affect gene expression
Official title: Roles for chromatin remodeler RSC and histone acetyltransferases in regulating chromatin structure and transcription
Funded at Oakland University · NIH-10579529 · Data updated 2026-11-12
This study is looking at how certain proteins that help organize our DNA can affect how genes work, especially when they have mutations that might lead to diseases like cancer or developmental disorders, and it’s for anyone interested in understanding the science behind these health issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 9, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $429,835 |
| NIH project number | 1R15GM148919-01 |
| Project ID | NIH-10579529 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with specific cancers or developmental disabilities associated with chromatin remodeling mutations.
✕Less likely to help
Patients without chromatin-related mutations or those with unrelated conditions may not benefit from this research.
What this research studies
This research focuses on understanding how changes in chromatin structure influence gene expression, particularly through the roles of chromatin remodelers and histone acetyltransferases. By studying the RSC complex, a key player in chromatin remodeling, the research aims to uncover how mutations in these proteins are linked to various diseases, including cancers and developmental disorders. The approach involves examining the interactions of these remodelers with DNA and nucleosomes in living cells to determine their functional significance. This could provide insights into the molecular mechanisms underlying gene regulation and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and developmental disorders linked to chromatin remodeling mutations.
How similar studies have gone: Previous research has shown that understanding chromatin dynamics can lead to significant advancements in cancer treatment, indicating a promising avenue for this investigation.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Govind, Chhabi K — Oakland University
- Study coordinator: Govind, Chhabi K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.