Investigating how chromatin modifications affect DNA repair in cancer cells
Project 3: Chromatin modifiers of BRCA-related DNA repair Pathways
This study is looking at how a protein called EHMT2 helps fix DNA damage, especially in people with BRCA-related cancers, to find new ways to improve treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11080261 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of chromatin modifiers, specifically a protein called EHMT2, in the DNA repair process, particularly in the context of BRCA-related pathways. By examining how EHMT2 is recruited to sites of DNA damage and its impact on the efficiency of DNA repair, the research aims to uncover potential therapeutic targets. The study involves analyzing the molecular mechanisms that regulate DNA repair and transcriptional silencing near DNA breaks, which could lead to new treatment strategies for cancers associated with BRCA mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with BRCA1 or BRCA2 mutations who are at risk for breast and ovarian cancers.
Not a fit: Patients without BRCA mutations or those with cancers unrelated to DNA repair pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance DNA repair mechanisms in patients with BRCA-related cancers.
How similar studies have performed: Previous research has shown promising results in targeting chromatin modifiers for cancer therapy, indicating that this approach may be viable.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Ganesan, Shridar — Rutgers Biomedical and Health Sciences
- Study coordinator: Ganesan, Shridar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.