Investigating how chorioamnionitis affects brain inflammation and injury in newborns
The role of chorioamnionitis-induced perinatal alterations of Heme-oxygenase-1 (HO-1) pathway on neuroinflammation and neonatal white matter injury
This study is looking at how an infection during pregnancy called chorioamnionitis affects newborns' brain health, and it will explore a specific protein that might help protect their brains from injury, with the hope of finding new ways to help these babies.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10907549 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of chorioamnionitis, an infection during pregnancy, on the development of brain inflammation and injury in newborns. The study will explore the role of a specific protein pathway, Heme-oxygenase-1 (HO-1), in these processes. By examining how this pathway is altered in affected infants, researchers aim to identify potential therapeutic targets to mitigate brain injury. The research will involve advanced techniques in neuroimmunology and neuroscience to gather data and insights.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns who have been exposed to chorioamnionitis and are at risk for brain injury.
Not a fit: Patients who are not newborns or who have not been exposed to chorioamnionitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect newborns from brain injury caused by infections during pregnancy.
How similar studies have performed: Previous research has shown promising results in understanding the effects of chorioamnionitis on neonatal outcomes, making this approach both relevant and potentially impactful.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Ozen, Maide — Johns Hopkins University
- Study coordinator: Ozen, Maide
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.