Investigating how cholinergic mechanisms affect cognitive decline in Lewy Body Dementia.
Official title: Cholinergic Mechanisms in Lewy Body Dementia
Funded at University of Florida · NIH-11065546 · Data updated 2026-11-12
This study is looking at how a brain chemical called acetylcholine affects thinking and memory problems in people with Lewy Body Dementia, and it hopes to find new ways to help improve these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $445,581 |
| NIH project number | 5R01NS132293-03 |
| Project ID | NIH-11065546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lewy Body Dementia or related dementias characterized by α-synuclein accumulation.
✕Less likely to help
Patients with cognitive impairments not related to Lewy Body Dementia or those with other forms of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the role of acetylcholine (ACh) in cognitive impairments associated with Lewy Body Dementia (LBD) and related conditions. It examines how the loss of cholinergic neurons in the basal forebrain affects executive function by disrupting ACh signaling in the brain's prefrontal cortex. By studying the relationship between α-synuclein accumulation and cholinergic dysfunction, the research aims to uncover potential therapeutic targets for improving cognitive function in patients with LBD. Patients may be involved in assessments that explore cognitive performance and brain function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with Lewy Body Dementia.
How similar studies have gone: Previous research has shown promising results in understanding cholinergic mechanisms in dementia, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Moehle, Mark S — University of Florida
- Study coordinator: Moehle, Mark S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.