Investigating how choline affects myelin formation in nerve cells
Official title: Choline-dependent metabolism in PNS myelination
Funded at Rutgers the State Univ of Nj Newark · NIH-10863991 · Data updated 2026-11-12
This study is looking at how choline helps build the protective covering around nerves, which is important for them to work properly, and it aims to find out how this process might help us understand and treat conditions where that covering is damaged.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | September 1, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $288,951 |
| NIH project number | 5R01NS118020-05 |
| Project ID | NIH-10863991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with demyelinating disorders or those at risk for such conditions.
✕Less likely to help
Patients with non-demyelinating neurological conditions are unlikely to benefit from this research.
What this research studies
This research focuses on understanding the role of choline in the formation of myelin, which is essential for proper nerve function. It examines how Schwann cells, which are responsible for myelinating peripheral nerves, import choline and how this process influences the synthesis of important lipids and the regulation of gene expression. By studying a specific choline transporter, CTL1, the research aims to uncover the biochemical pathways that affect myelination and potentially lead to new insights into demyelinating diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating demyelinating diseases, improving nerve function and patient outcomes.
How similar studies have gone: While the specific role of CTL1 in Schwann cells is being explored, similar research has shown promise in understanding lipid metabolism and myelination, indicating potential for success.
Where this research is happening
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Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Kim, Haesun a — Rutgers the State Univ of Nj Newark
- Study coordinator: Kim, Haesun a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.