Investigating how cholesterol signaling and metabolism affect health.
Official title: Structural and Functional Investigations on Cholesterol Signaling and Metabolism
Funded at Ut Southwestern Medical Center · NIH-10932847 · Data updated 2026-11-12
This study is looking at how cholesterol affects our cells and can lead to health problems like cancer and heart disease, so we can better understand how to prevent and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 22, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $467,400 |
| NIH project number | 5R35GM149533-02 |
| Project ID | NIH-10932847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be experiencing conditions related to cholesterol metabolism, such as cardiovascular diseases or certain cancers.
✕Less likely to help
Patients with conditions unrelated to cholesterol metabolism or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the role of cholesterol in cellular functions and its implications for diseases like cancer and cardiovascular conditions. By using advanced cell biological and structural techniques, the team will explore how cholesterol is processed and how it influences signaling pathways critical for cell growth and development. The research aims to uncover the mechanisms behind cholesterol-related diseases, particularly how disruptions in cholesterol signaling can lead to tumor formation and other health issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating diseases linked to cholesterol dysregulation.
How similar studies have gone: Previous research has shown promising results in understanding cholesterol's role in cell signaling and its implications for various diseases, indicating that this approach has potential for significant findings.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Li, Xiaochun — Ut Southwestern Medical Center
- Study coordinator: Li, Xiaochun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.