Investigating how cholesterol metabolism affects the development of cleft palate
Role of cellular metabolism in palate morphogenesis
This study is looking at how cholesterol levels in the body can affect the development of the palate, especially in cases of cleft palate, and it aims to find out how genetics and diet play a role, so we can better understand and potentially prevent this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10828358 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cholesterol metabolism in the formation of the palate, particularly how disruptions in cholesterol production can lead to cleft palate, a common congenital defect. The study examines genetic mutations and maternal diets that influence cholesterol levels and their impact on palate development. Using mouse models, researchers will explore the mechanisms by which cholesterol precursors affect cell proliferation and signaling pathways crucial for normal palate formation. The findings aim to uncover the biological processes involved in cleft palate development, which could inform prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals with a family history of cleft palate or those with dietary concerns related to cholesterol.
Not a fit: Patients who have already been diagnosed with cleft palate and have undergone surgical correction may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and interventions for preventing cleft palate in at-risk populations.
How similar studies have performed: Previous research has indicated a link between cholesterol metabolism and congenital defects, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Zhao, Zhongming — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Zhao, Zhongming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.