Investigating how cholesterol metabolism affects brain function in Alzheimer's Disease
Dysregulated cholesterol metabolism in Alzheimer's Disease astrocytes: Investigating contributions to neuronal dysfunction
This study is looking at how cholesterol in brain cells called astrocytes might affect Alzheimer's Disease, with the hope of finding new ways to help improve treatment for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10868519 on NIH RePORTER |
What this research studies
This research explores the role of cholesterol metabolism in Alzheimer's Disease (AD) by focusing on astrocytes, a type of brain cell that supports neurons. The study aims to understand how changes in cholesterol levels within these cells may contribute to neuronal dysfunction and inflammation, which are key features of AD. By examining the interactions between astrocytes and neurons, the research seeks to uncover potential mechanisms that drive the progression of Alzheimer's Disease. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting cholesterol metabolism in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of Alzheimer's Disease.
How similar studies have performed: Previous research has shown that targeting cholesterol metabolism in the brain may have therapeutic potential, indicating that this approach could be promising.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Burgado, Jillybeth — University of California, San Diego
- Study coordinator: Burgado, Jillybeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.