Investigating how cholesterol levels affect brain cells in Alzheimer's disease
Membrane cholesterol homeostasis in human brain cells derived from iPSCs
['FUNDING_R15'] · FLORIDA ATLANTIC UNIVERSITY · NIH-10974893
This study is looking at how cholesterol levels in brain cells might be linked to Alzheimer's disease, especially how certain gene changes can affect these levels, and it invites patients to help by sharing samples or joining related research.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA ATLANTIC UNIVERSITY (nih funded) |
| Locations | 1 site (BOCA RATON, UNITED STATES) |
| Trial ID | NIH-10974893 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the relationship between cholesterol homeostasis and Alzheimer's disease by examining human brain cells derived from induced pluripotent stem cells (iPSCs). The researchers will explore how mutations in the amyloid precursor protein (APP) influence cholesterol levels in brain cells and contribute to neurodegeneration. By studying these mechanisms, the research aims to uncover potential therapeutic targets for Alzheimer's disease. Patients may have the opportunity to contribute to this important work by providing samples or participating in related studies.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a family history of Alzheimer's disease or those carrying the APOE ε4 allele, which is associated with increased risk for the condition.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or who are not affected by cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting cholesterol regulation in the brain.
How similar studies have performed: Previous research has shown promising results in understanding the role of cholesterol in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
BOCA RATON, UNITED STATES
- FLORIDA ATLANTIC UNIVERSITY — BOCA RATON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, QI — FLORIDA ATLANTIC UNIVERSITY
- Study coordinator: ZHANG, QI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome